Nitroethane

Nitroethane a organic compound which is a oily liquid at normal temperature and pressure also similar in many ways to nitromethane. Used as a fuel additive and a precursor for explosives. In more common consumer products it is used as a component in artificial nail remover and ceiling sealant sprays. In it’s pure form it is colorless with a fruity odor.

nitroethane nitroethane molecular

The chemical formula of nitroethane is C2H5NO2. Producing the compound is done industrially by treating propane using nitric acid at a temperature of 350 to 450°C. This becomes a exothermic reaction that produces 4 major industrially nitroalkanes. These 4 are nitroethane, nitroethane, 1-nitropropane, and 2-nitropropane. Free radicals involved in this reaction are CH3CH2CH2O. These correspond to nitrite ester arising via homolysis. They are alkoxy radicals which are susceptible to C—C fragmentation reactions.

Another method to produce nitroethane using Victor Meyer reaction with bromoethane or  iodoethane combine with silver nitrite in diethyl ether solvent or using the Kornblum Modification with alkyl halides and the sodium nitrate salt with dimethyl sulfoxide or the dimethylformamide solvent.

Using condensations such as the Henry reaction nitroethane can convert to multiple compounds of a commercial interest. Using 3.4 dimethoxybenzaldehyde makes the precursor for a antihypertensive drug called methyldopa. Using two equivalents of formaldehyde which after hydrogenation produces 2-amino-2-methyl-1,3-propanediol then use oleic acid with that to give oxazoline that protonates to produce a cationic surfactant. Using unsubstituted benzaldehyde gives phenyl-2-nitropropene.

Nitroethane is used as a synthesis of controlled substances like amphetamines also used as chemical feedstock in clandestine labs. The overdose for rats is stated at 1100 mg/kg. There is evidence to support that chemical can cause genetic damage as well as damaging to the nervous system. Contact with the skin causes dermatitis in people. Kids have being known to be poison by drinking nail polish remover. In animals exposure has caused narcosis, edema, liver and kidney damage, pulmonary rales, dyspnea and lacrimation.